Anti-Abl
Anti-p150 | Host: Mouse | | Isotype: IgG1 | | Immunogen: a recombinant protein consisting of the carboxyl region of v-Abl protein fused to TrpE | | Form: Liquid | | Formulation: In 0.05 M sodium phosphate buffer, 50% glycerol. | | Preservative: None | | Positive Control: K562 (human bcr/abl), HL-60 (normal abl), and ANN-1 (murine abl) cells | | Negative Control: Normal human fibroblasts | | Comments: Recognizes the ~145 kDa c-Abl, the ~150 kDa mouse c-Abl, v-Abl proteins, and the Bcr/Abl translocation products in ALL (~190 kDa) and CML (~210 kDa). Does not inhibit protein tyrosine kinase activity. | | Ref.: Wiedemann, L.M., et al. 1988. Blood 71, 349. Stam, K., et al. 1985. N. Engl. J. Med. 313, 1429. Konopka, J.B., et al. 1984. Cell 37, 1035. Prywes, R., et al. 1983. Cell 34, 569. de Klein, A., et al. 1982. Nature 300, 765. Reynolds, F.H., Jr., et al. 1980. J. Virol. 36, 374. Reynolds, F.H., Jr., et al. 1978. Proc. Natl. Acad. Sci. USA 75, 3974. Witte, O.N., et al. 1978. Proc. Natl. Acad. Sci. USA 75, 2488. Abelson, H.T. and Rabstein, L.S. 1970. Cancer Res. 30, 2213. |
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