Host: Mouse

Isotype: IgG1

Immunogen: BALB/c SVA31 E7 cells

Epitope: a conformational epitope within amino acids 85-109

Form: Liquid

Formulation: In 50 mM sodium phosphate buffer, 0.2% gelatin.

Preservative: ≤0.1% sodium azide

Positive Control: SV-T2 cells

Negative Control: SK-OV-3 cells

Comments: Recognizes the ~53 kDa wild-type p53 protein in its native conformation in SV-T2 cells. Does not recognize mutant or denatured p53 protein.

Ref.: El-Deiry, W.S., et al. 1994. Cancer Res. 54, 1169. Greenblatt, M.S., et al. 1994.Cancer Res. 54, 4855. Barak, Y., et al. 1993. EMBO J. 12, 461. Lane, D.P. 1992. Nature 358, 15. Kastan, M.B., et al. 1991. Cancer Res. 51, 6304. Kastan, M.B., et al. 1992. Cell 71, 587. Kuerbitz, S.J. 1992. Proc. Natl. Acad. Sci. USA 89, 7491.