Anti-Breast Cancer Susceptibility Protein

Host: Mouse

Isotype: IgG1

Immunogen: recombinant human BRCA1

Epitope: within the N-terminal 304 amino acids of BRCA1

Form: Liquid

Formulation: In 50 mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.

Preservative: ≤0.1% sodium azide

Positive Control: MCF7 cells

Comments: Recognizes the ~220 kDa BRCA1 protein in MCF-7 cells. Does not cross-react with blood group antigens or growth factor receptors such as EGFR. Sold under license of U.S. Patent 5,753,441 and 6,162,897.

Ref.: Scully, R., et al. 1996. Science 272, 123. Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717. Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711. Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113. Merajver, S.D., et al. 1995. Clin. Can. Res. 1, 539. Merajver, S.D., et al. 1995. Nat. Genet. 9, 439. Struewing, J.P., et al. 1995. Nat. Genet. 11, 198. Thompson, M.E., et al. 1995. Nat. Genet. 9, 444. Futreal, P.A., et al. 1994. Science 266, 120. Miki, Y., et al. 1994. Science 266, 66. Wilson, C.A., et al. 1999. Nat. Genet. 21, 236.

Sold under license of U.S. Patents 5,753,441 and 6,162,897.