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| | Anti-Capsaicin Receptor (Ab-1) (824-838) Rabbit pAb |
|  | Cat. No. PC420 |
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Anti-Vanilloid Receptor | Host: Rabbit | | Isotype: IgG | | Immunogen: a synthetic peptide (EDAEVFKDSMVPGEK) corresponding to amino acids 824-838 of rat capsaicin receptor, conjugated to KLH | | Form: Liquid | | Formulation: In PBS. | | Preservative: ≤0.1% sodium azide | | Positive Control: Mouse spinal cord dorsal horn | | Comments: Recognizes the ~100 kDa capsaicin receptor protein in mouse spinal cord extract. | | Ref.: Caterina, M.J., et al. 1999. Nature 398, 436. Gau, A., et al. 1999. Eur. J. Neurosci. 11, 946. Michael, G.J., and Priestley, J.V. 1999. J. Neurosci. 19, 1844. Caterina, M.J., et al. 1997. Nature 389, 816. Szallasi, A. 1994. Gen. Pharmacol. 25, 223. Beven, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330. Fields, H.L. 1987. Pain (New York: McGraw-Hill). |
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Detection of mouse capsaicin receptor by immunoblotting. Sample: Whole tissue extract 60 µg) from mouse spinal cord (lanes 1,3,4; MWM, lane 2). Primary antibody: Anti-Capsaicin Receptor (Ab-1) (824-838) Rabbit pAb (Cat. No. PC420) (5 µg/ml, lane 3 or 10 µg/ml, lane 4) and Normal rabbit IgG (5 µg/ml, lane 1). Detection: chemiluminescence.
Detection of mouse capsaicin receptor by staining frozen sections. Sample: Mouse spinal cord dorsal horn. Primary antibody: Anti-Capsaicin Receptor (Ab-1) (824-838) Rabbit pAb (Cat. No. PC420) (5 mg/ml, panel B or 10 µg/ml, panel C) and normal rabbit IgG (5 µg/ml, panel A). Detection: DAB.
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| - S. Tamura, Y. Morikawa and E. Senba. (2005) TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Neuroscience 130, 223-228.
- Yi Dai, et al. (2004) Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. Journal of Neuroscience 24, 4293-4299.
- Rudolf Schicho, et al. (2004) Increased Expression of TRPV1 Receptor in Dorsal Root Ganglia by Acid Insult of the Rat Gastric Mucosa. European Journal of Neuroscience 19, 1811-1818.
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