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| | Anti-TACE (807 - 823) Rabbit pAb |
|  | Cat. No. PC491 |
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Anti-ADAM17
Anti-TNF-a Converting Enzyme | Host: Rabbit | | Isotype: IgG | | Immunogen: a synthetic peptide (ASFKLQRQNRVDSKETE) corresponding to amino acids 807-823 of human TACE | | Form: Liquid | | Formulation: In PBS. | | Preservative: ≤0.1% sodium azide | | Positive Control: HeLa or Jurkat cells | | Comments: Recognizes the ~130 kDa TACE protein in HeLa and Jurkat cells. | | Ref.: Mizul, Y., et al. 1999. Gene. 233, 67. Buxbaum, J.D., et al. 1998. J. Biol. Chem. 273, 27765. Giegel, D.A. and Cheplinm, D.D. 1998. Agents Actions Suppl. 491, 1. Peschon, J.J., et al. 1998. Science 282, 1281. Black, R.A., et al. 1997. Nature 385, 729. Moss, M.L., et al. 1997. Nature 385, 733. |
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Detection of human TACE by immunoblotting. Samples: Whole cell lysate from HeLa cells (lanes 1,3) or Jurkat cells (lanes 2,4). Primary antibody: Anti-TACE (807 - 823) Rabbit pAb (Cat. No. PC491) pre-incubated without blocking peptide (lanes 1,2) or with blocking peptide (lanes 3,4) (1:500). Detection: chemiluminescence.
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| - Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119.
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