Host: Rabbit

Isotype: IgG

Immunogen: a synthetic phosphopeptide (DCSGLSpSQSDILT) corresponding to amino acids 1381-1393 surrounding the Ser 1387 phosphorylation site of human BRCA1, conjugated to diphtheria toxoid

Form: Liquid

Formulation: Serum adsorbed and diluted in PBS.

Preservative: None

Positive Control: C3ABR lymphoblastoid cells exposed to ionizing radiation

Comments: Recognizes the ~220 kDa BRCA1 protein phosphorylated at Ser1387. Does not recognize BRCA1 phosphorylated at non-related sites or unphosphorylated BRCA1.

Ref.: Gatei, M., et al. 2000. Cancer Res. 60, 3299. Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717. Scully, R., et al. 1996. Science 272, 123. Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711. Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113. Merajver, S.D., et al. 1995. Nat. Genet. 9, 439. Merajver, S.D., et al. 1995. Clin. Caner Res. 1, 539. Struewing, J.P., et al. 1995. Nat. Genet. 11, 198. Thompson, M.E., et al. 1995. Nat. Genet. 9, 444. Futreal, P.A., et al. 1994. Science 266, 120. Miki, Y., et al. 1994. Science 266, 66.