| Host: Rabbit | | Isotype: IgG | | Immunogen: a synthetic phosphopeptide [LEQHGpSQPSNSY(C)] corresponding to amino acids 1418-1429 of human BRCA1, conjugated to diphtheria toxoid | | Form: Liquid | | Formulation: Serum diluted in PBS. | | Preservative: None | | Purity: diluted serum | | Positive Control: C3ABR lymphoblastoid cells exposed to ionizing radiation | | Comments: Recognizes the ~220 kDa BRCA1 protein phosphorylated at Ser1423. Does not recognize BRCA1 phosphorylated at non-related sites or unphosphorylated BRCA1. | | Ref.: Gatei, M., et al. 2000. Cancer Res. 60, 3299. Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717. Scully, R., et al. 1996. Science 272, 123. Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711. Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113. Merajver, S.D., et al. 1995. Nat. Genet. 9, 439. Merajver, S.D., et al. 1995. Clin. Caner Res. 1, 539. Struewing, J.P., et al. 1995. Nat. Genet. 11, 198. Thompson, M.E., et al. 1995. Nat. Genet. 9, 444. Futreal, P.A., et al. 1994. Science 266, 120. Miki, Y., et al. 1994. Science 266, 66. | |