Host: Rabbit

Isotype: IgG

Immunogen: a synthetic peptide (GWIQDQGGWDGLLSYF) corresponding to amino acids 150-165 of human Bax

Form: Liquid

Formulation: In 0.05 M sodium phosphate buffer, 50% glycerol.

Preservative: None

Positive Control: Doxorubicin-treated HeLa or MCF7 cells, mouse intestine tissue, or human lymph node tissue

Negative Control: Untreated HL-60 or HS27 cells

Comments: Recognizes the ~21 and 44-50 kDa bands monomeric and dimeric forms, respectively, of Bax in induced HeLa or MCF-7 cells lysate. The immunogen, Bax Peptide (Cat. No. PP51) is available for competition studies.

Ref.: Bargou, R.C., et al. 1995. Int. J. Cancer 60, 854. Hanada, M., et al. 1995. J. Biol. Chem. 270, 11962. Miyashita, T. and Reed, J.C. 1995. Cell 80, 293. Korsmeyer, S.J., et al. 1993. Semin. Cancer Biol. 4, 327. Oltvai, Z.N., et al. 1993. Cell 74, 609.