Liquid. In 100 mM NaCI, 20 mM HEPES, pH 7.4. AVOID FREEZE/THAW CYCLES. CrmA (cowpox viral serpin cytokine response modifier A) is purified from E. coli transformed with a construct containing the full-length coding region of the CrmA gene and 7 additional amino acids that do not affect the activity. CrmA is a natural inhibitor of human caspase-1 and granzyme B, enzymes that are involved in apoptosis. Ref.: Snipas, S.J., et al. 2001. Biochem. J. 357, 575. Quan, L.T., et al. 1995. J. Biol. Chem. 270, 10377. |
