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| | PhosphoDetect™ Anti-DARPP32 (pThr75) Rabbit pAb |
|  | Cat. No. PS1005 |
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| Host: Rabbit | | Isotype: IgG | | Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Thr75 phosphorylation site of DARPP32 | | Form: Liquid | | Formulation: In 150 mM NaCl, 10 mM HEPES, 100 µg/ml BSA, 50% glycerol, pH 7.5. | | Preservative: None | | Positive Control: Rat caudate extract | | Comments: Detects the ~32 kDa DARPP32 phosphorylated at Thr75. DARPP32 (dopamine and cyclic AMP-regulated phosphoprotein) is a cytosolic protein that plays an important role in dopaminergic neurotransmission and normal brain function. | | Ref.: Svenningsson, P., et al. 2003. Science 302, 1412. Lindskog, M., et al. 2002. Nature (London) 418, 774. Maldve, R.E., et al. 2002. Nature Neurosci. 5, 641. Greengard, P., et al. 2001. Science 294, 1024. Bibb, J.A., et al. 1999. Nature (London) 402, 669. Fienberg, A.A., et al. 1998. Science 281, 838. Walaas, S.I., et al. 1984. J. Neurosci. 4, 84. |
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Detection of rat DARPP32, phosphorylated at Thr75, by immunoblotting. Samples: Whole tissue extract from rat caudate slices incubated without okadaic acid (control, left lane) or with okadaic acid (right lane). Primary antibody: PhosphoDetect™ Anti-DARPP32 (pThr75) Rabbit pAb (Cat. No. PS1005) (1:1000). Detection: chemiluminescence.
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