Heat Shock Protein 27 ELISA Kit | Format: 96-well plate | | Form: 96 Tests | | Detection Method: Colorimetric | | Species Reactivity: human | | Assay Range: 0.02-1 ng/ml | | Assay Time: 3.5 h | | Sample Type: Cell lysates, plasma, serum, tissue extracts | | Kit Contents: Anti-Hsp27 Coated 96-Well Plate, Hsp27 Standard, Lysis Buffer, Assay Diluent, Detector Antibody, Wash Buffer, HRP-Conjugate, TMB, Stop Solution, and a user protocol. | | Comments: Hsp27 over-expression has been reported to be a negative regulator of apoptosis. Elevated levels of Hsp27 may be associated with aggressive growth and cell invasion, which often results in poor prognosis in breast, ovarian, and prostatic carcinomas. In neuronal cells, Hsp27 over-expression promotes survival following growth factor withdrawal or other stress. | | Ref.: Cornford, P.A., 2000. Cancer Res. 60, 7099. Arts, H.J., 1999. Int. J. Cancer 84, 234. Garrido, C., et al. 1997. Cancer Res. 57, 2661. Mehlen, P., et al. 1997. J. Biol. Chem. 272, 31657. Mairesse, N., et al. 1996. Cell Biol. Int. 20, 205. Minowada, G., and Welch, W. 1995. J. Biol. Chem. 270, 7047. Piotrowicz, R.S. 1995. FASEB J. 9, 1079. Rouse, J., et al. 1994. Cell 78, 1027. Oesterreich, S., et al. 1993. Cancer Res. 53, 4443. Landry, J., et al. 1991. J. Biol. Chem. 267, 794. Thor, A., et al. 1991. J. Natl. Cancer Inst. 83, 170. | |